- Galastop contains the drug cabergoline, which is a powerful and long lasting inhibitor of prolactin secretion
- Prolactin is the key hormone for lactogenesis and the initiation and maintenance of lactation after parturition, as well being associated with the clinical signs associated with false pregnancy
- It is commonly used in the bitch for the treatment of false pregnancy and the drying up of lactation
- Treatment of false pregnancy in bitches – inhibition of prolactin secretion results in a rapid resolution of the signs of false pregnancy, including lactation and behavioural change
- Suppression of lactation in bitches – inhibition of prolactin secretion results in a rapid cessation of lactation and a reduction in the size of the mammary glands. This may be required in some clinical circumstances, e.g. following removal of pups soon after birth or early weaning.
Instructions of use
- Administer orally either directly into mouth or by mixed with food
- Dosage is 0.1ml/kg/bodyweight (equivalent to 5μg/kg bodyweight of cabergoline) once daily for 4-6 days
For dogs less than 5kg bodyweight it is advisable to measure the dosage in drops, 3 drops being equivalent to 0.1ml.
- If the signs fail to resolve after a single course of treatment, or if they recur after the end of treatment, then the course of treatment may be repeated
- For treatment of false pregnancy, clinical studies have demonstrated efficacy between 80 – 100%. Behavioural signs are alleviated first (within a few days) followed by reduction in mammary gland enlargement and finally suppression of lactation.
Precautions of use
- Generally well tolerated with few side effects and high safety index
- Do not use in pregnant animals since Galastop may cause abortion
- Do not use in lactating bitches unless suppression of lactation is required
- Vomiting, anorexia or drowsiness may occur in some animals within the first 1-2 days of treatment. There is no need to discontinue treatment unless signs are severe or persist beyond the second dose
- May potentially induce a mild transient hypotension. This is usually clinically insignificant but it is advised not to use in animals concurrently being treated with hypotensive drugs, such as acepromazine or frusemide or directly after surgery, whilst the animal is still under the influence of anaesthetic agents. It is also advisable to stop galastop use for 4 days prior carrying out a general anaesthetic
- If an overdose is given, general supportive measures should be taken to remove any unabsorbed drug and maintain blood pressure. The administration of a dopamine antagonist, e.g. metoclopramide, could also be considered.
- Do not administer concurrently with drugs that have a dopamine antagonist activity (such as phenothiazines, butyrophenones and metoclopramide) as these might reduce the prolactin inhibiting effects