Cevazuril

Toltrazuril: full efficacy

Toltrazuril: fast action - maintained performance

Toltrazuril: single dose - long lasting effectA 5% oral solution of toltrazuril, ensuring perfect efficacy and safety.

Control of coccidiosis using toltrazuril prevents damage to the intestinal mucosa caused by the developmental stages of Isospora suis thus preserving digestive function and maintaining optimal growth rate.

Farmer friendly - Piglet perfect !
Pack sizes appropriate for farms of all sizes with pump dispensers for easy and accurate administration.

Composition:  

Toltrazuril 50mg in 1ml of suspension. Excipients: Sodium benzoate, Sodium propionate, Docusate sodium, Aluminium magnesium silicate, Xanthan gum, Propylene glycol, Citric acid monohydrate, Simeticone emulsion, purified water.

Indications:  prevention of clinical signs of coccidiosis in neonatal piglets.

Contraindications:  none.

Special warnings for target species:  It is recommended to treat all piglets in a litter.Interaction with other medicinal products: None known. There is no interaction in combination with iron supplementation.

Dosage:  Oral use. Individual animal treatment. Each piglet to be treated on day 3-5 of life with a single oral dose of 20 mg toltrazuril/kg body weight corresponding to 0.4 ml oral suspension per kg body weight.

Withdrawal period:  Meat and offal: 77 days.

Pharmacodynamic properties:  Toltrazuril is a triazinon derivative. It acts against coccidia of the genus Isospora. It is acting against all intracellular development stages of coccidia: merogony (asexual multiplication) and gamogony (sexual phase). All stages are destroyed, thus the mode of action
is coccidiocidal. Presentation: High density polyethylene bottle 250ml and 1000 ml.

Shelf life Shelf-life of the veterinary medicinal product as packaged for sale:  2 years.

Shelf-life after first opening the immediate packaging: 6 months

Toltrazuril

Highly efficacious and active on all developmental stages.  
Toltrazuril acts on all intracellular development stages of coccidia. It also reduces oocysts production even if administered after the appearance of the first oocysts in the faeces of the host (1).

Treat every batch.
Discontinuation of toltrazuril administration even in a single batch of piglets can lead to the return of diarrhoea and decreased growth rate in subsequent batches. On a farm with a history of toltrazuril use in previous batches, piglets receiving toltrazuril performed better than those in the control group that were not treated (3).

Control
Treated Interruption of the systematic treatment leads to the return of coccidiosis.

Coccidiosis  

Widespread disease.  Neonatal piglet coccidiosis causes diarrhoea in suckling piglets worldwide
and is caused by the intra-cellular coccidial parasite, Isospora suis. It may be found anywhere pigs are raised with an on-farm prevalence ranging between 40 to 100% (4,5).

Serious damage.  Newborn suckling piglets are especially sensitive to infection from I.suis. Sporulated
oocysts invade the small intestine before multiplication of the different developmental stages in the enterocytes of the jejunum and ileum leading to serious damage of the
epithelial layers, villus atrophy and necrotic enteritis.

Huge impact.  Infection may result in lost daily gain amounting to almost 2 kg up to 28 days
of age due to diarrhoea (6).

Good hygiene is not enough.  There is no direct link between levels of hygiene and clinical coccidiosis (7).Exposure of Isospora oocysts - even to cresol based disinfectants – does not prevent infection.
Once established, diarrhoea may be reduced, but not eliminated (8).

Bibliography:
1) Mehlhorn H G. 1984; Z Parasitenkd 70, 173-182
2) Boehne B., 2006; Proc IPVS Denmark, 275
3) Rypula K , 2008; Proc IPVS Durban 346
4) Lindsay D.S., 2006, Coccidia and other protozoa,
in Diseases of swine, Straw B., 861-873
5) Torres A, 2004; Proc. IPVS Germany, 234
6) Mundt, H.C.2006; Parasitol Res. 98, 167-175
7) Martineau G-P 2000; Parasitology Research Vol.86, Nr 10 , 834-837
8) Koudela B. 2002; Veterinarstvi, 52(10) p. 453-454