Cevac Chlamydia

Cevac Chlamydia

Cevac Chlamydia

Vaccine against enzootic abortion

  • A live attenuated Chlamydophila abortus strain IB vaccine for active immunisation against enzootic abortion in sheep. Helps prevent abortion and reduce excretion

    Safer shock-proof vial and compact box

    Special anti-condensation cardboard & aluminium box for cold-storage containing:

    • Freeze-dried powder in a plastic shockproof tube

    • A vial of solvent

    The freeze-dried powder and solvent come together in a smaller box

    Licensed for use with toxoplasmosis vaccine

  • CEVAC® CHLAMYDOPHILA

    Freeze dried vaccine and diluent.

    COMPOSITION

     For one vaccine dose of 2ml: live attenuated freeze dried vaccine containing Chlamydophila abortus (at least 105 IFU per dose). Diluent 2ml.

    USES 

    For the active immunisation of susceptible breeding sheep as an aid in the prevention of
    abortion caused by Chlamydophila abortus infection and to reduce excretion of Chlamydophila abortus in infected animals.

    INDICATIONS For breeding sheep, active immunisation against enzootic abortion.

    CONTRA INDICATIONS Do not vaccinate animals less than 4 weeks before mating. Do not vaccinate pregnant animals. Do not vaccinate animals which are being treated with antimicrobials, particularly tetracyclines. Interaction with other medicinal products and other forms of interaction Safety and efficacy data are available which demonstrate that this vaccine can be administered the same day but not mixed with a commercial Toxoplasma gondii vaccine containing live tachyzoites of the S48 strain. However, other live vaccines should not be administered within 4 weeks of the administration of CEVAC® Chlamydophila.

    Undesirable effects A transient temperature rise may be observed after vaccination (average of 1.5°C for a maximum of 3 days).

    Dosage and method of administration 2 ml of reconstituted vaccine by intramuscular or subcutaneous injection. Ewe lambs, where it is intended to breed from them, may be vaccinated from 5 months of age. Shearlings and older ewes should be vaccinated during the 4 month period prior to mating. Withdrawal
    periods Animals should not be slaughtered for human consumption until at least 7 days after vaccination.

    PRECAUTIONS

    Operators should wear gloves when handling the vaccine. CEVAC® Chlamydophila should not be handled by pregnant women or women of child bearing age as the vaccine may cause abortion. CEVAC® Chlamydophila should not be handled by people who are immuno-deficient. Care should be taken to prevent self administration. If this occurs seek immediate medical advice. For animal treatment only. Keep out of the reach of children.

    STORAGE

     Keep refrigerated between 2 and 8ºC and protect from light. After reconstitution keep cool and use within 2 hours.

    DISPOSAL Discard of any unused vaccine safely: empty containers and all used equipment into an Approved Disinfectant, prior to disposal by incineration.

    PRESENTATION Box with vial containing 20 doses of freeze dried vaccine and bottle with 40ml diluent.

    LEGAL CATEGORY POM-V MARKETING

    AUTHORISATION NUMBER Vm 15052/4031.

  • Chlamydiosis is a disease caused by Chlamydophila abortus, a small Gram-negative bacterium that only multiplies in the cytoplasm of eukaryotic cells.  This bacterium, which has a tropism for ruminants’
    placentas, has two forms:

    • The elementary body: extra-cellular, infectious, metabolically inactive and resistant in external media.
    • The reticulate body: intra-cellular, metabolically active and sensitive to antimicrobials.

    The main cause of abortion

    Chlamydiosis is the main cause of infectious abortion of sheep in the UK. Approximately 50% of diagnosed infectious ovine abortions are caused by Chlamydophila abortus. In a newly infected flock,
    30 - 60% of pregnant ewes may abort during the first two years.

    The effects of chlamydiosis in small ruminants are mainly:
    • abortion towards the end of pregnancy
    • premature births
    • birth of frail lambs which soon die

    Other possible symptoms are: epididymitis, pneumonia, conjunctivitis, arthritis, etc.

    CHLAMYDIOSIS - A ZOONOTIC DISEASE

    Abortive chlamydiosis is disease that is especially dangerous pregnant women, who should contact with the animals, in during lambing.

    Not only does Chlamydophila cause miscarriages, but it be accompanied by serious
    complications that require hospitalisation.

    A flare-up in abortions

    In a flock, aborting ewes excrete massive amounts of Chlamydophila abortus in the placenta and the amniotic fluid. This leads to other ewes being contaminated, most often via the oral-nasal route.

    Of these newly infected ewes, those that are pregnant are likely to abort and some of the other ewes become healthy carriers of the infection and may abort during their next pregnancy.
    This contamination phenomenon largely explains how infection spreads within a flock.

    Over 2 to 3 years, abortions are seen to flare up, then the abortion rate drops to below 10%, before a new bout of abortions occurs in first-time lambers and new replacement animals. Ewes that have aborted usually become immune although the Moredun Research Institute recently suggested in 20% of ewes that abort or produce weak infected lambs, the Chlamydophila abortus can lie dormant until the next pregnancy when it becomes activated and infects the placenta and foetus.

    Lambs can be born infected or become infected from aborting ewes. These typically abort themselves at the first (occasionally second) pregnancy.